Rossella Di Giaimo

This study uses cerebral organoids to show that EPM1 mutations disrupt neural cell fate specification through intrinsic and extrinsic mechanisms involving EVs and SHH signaling.

This study investigates neuronal hyperactivity in human cerebral organoids derived from individuals with grey matter heterotopia, identifying functional and structural changes linked to the condition.

The paper investigates how extracellular vesicles (EVs) mediate developmental cues during brain development and disease, finding altered EV composition and function in neurodevelopmental disorders.

The paper shows that extracellular environment factors, specifically extracellular vesicles, influence neuronal differentiation and migration by altering transcriptomic profiles in neural progenitor cells.

The paper identifies a novel tripartite CRH circuit connecting extended amygdala and basal ganglia that drives arousal and avoidance behaviour through CRH receptor 1 in the substantia nigra.

The paper investigates how glucocorticoid receptor activation affects neuronal development in fetal human brain organoids using single-cell transcriptomics, finding cell-type specific impacts on differentiation and behavior-related gene expression.