Author

Jingshing Wu

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Genomics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Achal M Gowda· 1 shared Ana Maria GomeziD· 1 shared Benoit G. BruneauiD· 1 shared Bjorn C KnollmanniD· 1 shared Boris KricheliD· 1 shared Charlotte UetrechtiD· 1 shared Claudia E. KorcarziD· 1 shared Daniel J. BlackwelliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperPhysiology

Achal M Gowda

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

RyR2-Mediated Ca2+ Leak Drives Progressive Arrhythmogenic Cardiomyopathy

Jingjing Zheng, Daniela Ponce-Balbuena, Sergio Estrada, Li Xiao, Erick Benjamin Ríos Pérez, Achal M Gowda, Claudia E. Korcarz, Kristin M Hansen, Daniel J. Blackwell, Madelaine P Thorpe, Wendell Scott Akers, Jingshing Wu, Jeffrey N Johnston, Ana Maria Gomez, Jean-Pierre Benitah, , Francisco J. Alvarado

This study shows that RyR2-mediated Ca2+ leak causes arrhythmias and progressive cardiomyopathy in rabbits, identifying RyR2 as a therapeutic target.

bioRxiv · Nov 3, 2026 · PreprintPhysiology

Structural variants in human congenital heart disease disrupt distal genomic regulatory contacts of developmental genes

Jodi Lee, Jingshing Wu, Maureen Pittman, Zoe L. Grant, Shuzhen Kuang, Daniel Quiat, Sarah U. Morton, Geoffrey Fudenberg, Michela Traglia, Kelly Hayes, Ritu Kumar, Benoit G. Bruneau, Katherine S. Pollard

The paper develops a machine-learning model to predict how structural variants disrupt 3D chromatin structure in congenital heart disease and validates its predictions using induced pluripotent stem cells.

bioRxiv · Mar 2, 2026 · PreprintGenomics

Structural Heterogeneity of Proteoform-Ligand Complexes in AMP-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry

Hsin‐Ju Chan, Boris Krichel, Liam J. Bandura, Emily A. Chapman, Holden T. Rogers, Matthew S. Fischer, David S. Roberts, Zhan Gao, Man‐Di Wang, Jingshing Wu, Charlotte Uetrecht, Song Jin, Ying Ge

This study uses integrated top-down mass spectrometry to reveal structural heterogeneity in AMPK proteoform-ligand complexes, uncovering new insights into kinase regulation.

Journal of the American Chemical Society · Aug 14, 2025Peer-reviewedBiochemistry