Kris C. Wood

CDK8 Inhibition Releases the Muscle Differentiation Block in Fusion-driven Alveolar Rhabdomyosarcoma

This study identifies CDK8 inhibition as a therapeutic strategy for alveolar rhabdomyosarcoma by inducing myogenic differentiation and impairing tumor growth through a mechanism involving the Mediator kinase module, SAGA complex, and SIX4.

BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance

This study identifies BRCA1-A and LIG4 complexes as mediators of ecDNA biogenesis and shows their role in cancer drug resistance.

Chromosomal instability and chromosome 17p loss drive convergentNDE1 synthetic lethality in metastatic cancer cells

The paper identifies NDE1 as a synthetic lethal target in metastatic cancer cells driven by chromosomal instability and Chr17p loss.

Pathway Coessentiality Mapping Reveals Complex II is Required for de novo Purine Biosynthesis in Acute Myeloid Leukemia

The paper identifies Complex II's role in de novo purine biosynthesis in AML using CRISPR and metabolomic data, showing it as a therapeutic target.

Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization

The paper identifies 10 PTEN enhancers and proposes a new model of enhancer organization that includes spatial separation of functional and structural elements.

Evolved resistance to GAPDH inhibition results in loss of the Warburg Effect but retains a different state of glycolysis

This study evolves resistance to GAPDH inhibition and shows that cells lose the Warburg Effect but maintain a distinct glycolytic state with different metabolic dependencies.

Label propagation defines signaling networks associated with recurrently mutated cancer genes

The paper uses label propagation to analyze gene expression signatures from cancer mutations, identifying signaling networks and drug response markers across multiple tumor types.