Thomas W van Ravesteyn

The paper shows that polyploid cells in intestinal regeneration are cleared through mitotic errors despite centrosome clustering, leading to rapid loss of faulty lineages.

The paper identifies binary karyotypes as universally selected in cancers and yeast, showing lower TP53 mutation rates and increased fitness compared to other aneuploid karyotypes.

The paper identifies a universal scaling law for mitotic spindles across eukaryotes, showing metaphase plate width scales with genome size following a power law with an exponent of ~1/3, driven by chromosome crowding.