Nenad Pavin

This study resolves a paradox in spindle length control by showing that coordinated regulation at both microtubule ends allows spindle length and poleward flux to vary independently.

The paper shows that slowing microtubule retrograde flow is essential for axon and dendrite development and maintenance through a unified mechanism.

The paper identifies binary karyotypes as universally selected in cancers and yeast, showing lower TP53 mutation rates and increased fitness compared to other aneuploid karyotypes.

The paper identifies a universal scaling law for mitotic spindles across eukaryotes, showing metaphase plate width scales with genome size following a power law with an exponent of ~1/3, driven by chromosome crowding.

The paper introduces a physical model to explain chromosome congression by analyzing forces from motor proteins and passive crosslinkers in the mitotic spindle.

This study investigates Rac1 activity dynamics in Dictyostelium discoideum using a fluorescent probe and a reaction-diffusion model, revealing oscillatory patterns and new colocalization regimes.