Israel Salguero

This study presents a comprehensive catalog of human double-strand break repair genes using genome-wide knockout data, revealing novel mechanisms and factors involved in DSB repair.

This study shows that cytoplasmic localization of RNR is essential for genome stability, as nuclear localization causes DNA replication defects and increased mutagenesis in fission yeast.

This study identifies MDC1's role in replication fork restart and shows its loss leads to chemoresistance in BRCA1/2-deficient mammary tumors.

The paper investigates mutagenic mechanisms of cancer-associated DNA polymerase ε alleles, showing that exonuclease domain mutations cause ultra-mutagenesis with mutation patterns similar to cancer Signature 14.