Abdelmoneim Eshra

The intracellular Ca2+ sensitivity of transmitter release from neocortical boutons

The paper measures the Ca2+ sensitivity of Syt1-triggered release in neocortical synapses and finds it has high affinity and cooperativity.

Ketamine potentiates a central glutamatergic presynapse

This study shows ketamine increases presynaptic glutamate release in cerebellar synapses by enhancing calcium influx and vesicle readiness, suggesting a direct presynaptic mechanism for its antidepressant effects.

Calcium dependence of neurotransmitter release at a high fidelity synapse

The paper investigates Ca2+-dependence of synaptic vesicle recruitment, priming, and fusion at cerebellar mossy fiber synapses, revealing distinct Ca2+ sensors for each step.

Gradients in the cerebellar cortex enable Fourier-like transformation and improve storing capacity

The paper identifies biophysical gradients in cerebellar granule cells that enable Fourier-like transformation of mossy fiber inputs and enhance spike-timing precision.

HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

This study shows HCN channels modulate action potential velocity and fidelity in central axons through cAMP and neuromodulators, with implications for energy consumption and temporal delays.