Edward D. B. Lopatto

This study designs miniprotein inhibitors targeting bacterial adhesins to prevent and treat urinary tract infections.

This paper develops a computational method to design glycoproteins with controlled N-linked glycan composition by encoding glycan location and structure into amino acid sequences.

This study shows that the lac operon in uropathogenic E. coli enables host glycan utilization, enhancing intracellular growth and infection dissemination.

This study identifies two monoclonal antibodies against FimH adhesin that protect mice from E. coli UTI by sterically blocking FimH function, offering an antibiotic-sparing treatment strategy.