Top-down control of water intake by the endocannabinoid system

Zhe Zhao; Edgar Soria Gómez; Marjorie Varilh; Francisca Julio‐Kalajzić; Astrid Cannich; Adriana Castiglione; Léonie Vanhoutte; Alexia Duveau; Philippe Zizzari; Anna Beyeler; Daniela Cota; Luigi Bellocchio; Arnau Busquets-García; Giovanni Marsicano

doi:10.1101/729970

NeurosciencebioRxivAug 9, 2019

Preprint

Top-down control of water intake by the endocannabinoid system

Zhe Zhao iD, Edgar Soria Gómez iD, Marjorie Varilh, Francisca Julio‐Kalajzić, Astrid Cannich, Adriana Castiglione, Léonie Vanhoutte, Alexia Duveau iD, Philippe Zizzari iD, Anna Beyeler iD, Daniela Cota iD, Luigi Bellocchio iD, Arnau Busquets-García iD, Giovanni Marsicano iD

Abstract

Water intake is regulated by neocortical top-down circuits, but their identity and the cellular mechanisms involved are scantly known. Here, we show that endogenous activation of type-1 cannabinoid receptors (CB1) promotes water intake and that endocannabinoid modulation of excitatory projections from the anterior cingulate cortex to the basolateral amygdala is sufficient to guarantee physiological drinking. These data reveal a new circuit involved in the homeostatic control of water intake.

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