Marjorie Varilh

Standardized brain and plasma EV enrichment pipeline validated for Single sample multi-Omic and fatty acids applications in Mouse and Human

The paper presents a standardized workflow for multi-omic profiling of brain and plasma-derived EVs from minimal human and mouse material, revealing tissue-specific and species-specific molecular signatures.

Cannabinoids regulate an insula circuit controlling water intake

This study identifies CB1 receptor-mediated circuit mechanisms in the insula that regulate water intake, showing distinct roles of anterior and posterior insula projections to the basolateral amygdala.

An unconventional GABAergic circuit differently controls pyramidal neuron activity in two visual cortical areas via endocannabinoids

The paper identifies a differential role of CB1-expressing interneurons in controlling pyramidal neuron activity in primary and secondary visual cortical areas through distinct endocannabinoid mechanisms.

Astroglial calcium transfer from endoplasmic reticulum to mitochondria determines synaptic integration

The paper shows that mtCB1 receptor activation in astrocytes regulates calcium transfer from ER to mitochondria, influencing synaptic integration and plasticity.

Top-down control of water intake by the endocannabinoid system

The paper identifies a circuit involving endocannabinoid modulation of excitatory projections from the anterior cingulate cortex to the basolateral amygdala that promotes water intake.

Specific hippocampal interneurons shape consolidation of recognition memory

This study identifies a specific subclass of hippocampal interneurons that regulate recognition memory consolidation through CB1 receptor signaling and GABAergic inhibition.