Author

Rohit Joshi

University of PennsylvaniaORCID 0000-0001-8875-4576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:imaging· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Aayush KantiD· 2 shared Abhijit MajumderiD· 2 shared Monika DhankhariD· 2 shared Vinayak VinayakiD· 2 shared Vivek B. ShenoyiD· 2 shared Zixian GuoiD· 2 shared Darshan ShahiD· 1 shared Diana Isabel Cruz· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

Aayush KantORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Osmotic Coupling of Mechanics and Epigenetics Regulates Chromatin Phase Organization

Aayush Kant, Monika Dhankhar, Rohit Joshi, Zixian Guo, Vinayak Vinayak, Diana Isabel Cruz, Kedi Wang, Ivan Vladimirovich Surovtsev, Megan King, Abhijit Majumder, Jung-Hwan Lee, Hae-Won Kim, Elizabeth Hinde, Guilherme P. F. Nader, Vivek B. Shenoy

This study develops a model linking nuclear hydration to chromatin phase organization and mechanics, showing how osmotic and mechanical cues influence chromatin structure through water content and histone dynamics.

bioRxiv · Oct 30, 2026 · PreprintBiophysics

Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution Imaging

Monika Dhankhar, Zixian Guo, Aayush Kant, Ramin Basir, Rohit Joshi, Vinayak Vinayak, Su Chin Heo, Robert L. Mauck, Melike Lakadamyali, Vivek B. Shenoy

This study combines theoretical modeling and high-resolution imaging to reveal how chromatin-lamina interactions and environmental cues influence LAD formation and thickness in hMSCs.

Nature Communications · Aug 25, 2025Peer-reviewedBiophysics

Histone acetylation alters nuclear morphology and architecture of human mesenchymal stem cells in rigidity dependent manner

Rohit Joshi, Darshan Shah, Kareenhalli Viswanath Venkatesh, Abhijit Majumder

This study shows that histone acetylation via HDACi alters nuclear morphology in hMSCs depending on substrate rigidity, with effects on soft substrates being reversible by HDACi treatment.

Soft Matter · Jan 1, 2025Peer-reviewedCell Biology