Author

Vinayak Vinayak

University of PennsylvaniaORCID 0000-0002-4597-6934Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:imaging· 3 Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:Hi-C· 2 Organism:human· 2

Frequent Co-Authors

Vivek B. ShenoyiD· 5 shared Aayush KantiD· 3 shared Zixian GuoiD· 3 shared Elena CambriaiD· 2 shared Marie A. FloryaniD· 2 shared Melike LakadamyaliiD· 2 shared Monika DhankhariD· 2 shared Ramin BasiriD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersBiophysics

Vivek B. ShenoyORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Osmotic Coupling of Mechanics and Epigenetics Regulates Chromatin Phase Organization

Aayush Kant, Monika Dhankhar, Rohit Joshi, Zixian Guo, Vinayak Vinayak, Diana Isabel Cruz, Kedi Wang, Ivan Vladimirovich Surovtsev, Megan King, Abhijit Majumder, Jung-Hwan Lee, Hae-Won Kim, Elizabeth Hinde, Guilherme P. F. Nader, Vivek B. Shenoy

This study develops a model linking nuclear hydration to chromatin phase organization and mechanics, showing how osmotic and mechanical cues influence chromatin structure through water content and histone dynamics.

bioRxiv · Oct 30, 2026 · PreprintBiophysics

IntravChip: a vascularized and perfused microfluidic model of the primary tumor microenvironment to collect intravasated tumor cells

Marie A. Floryan, Alessandro Cordiale, Heather Jensen, Julie Chen, Zixian Guo, Vinayak Vinayak, Sina Kheiri, Ritu Raman, Vivek B. Shenoy, Elena Cambria, Roger Dale Kamm

The paper introduces IntravChip, a microfluidic platform to study tumor cell intravasation and collect intravasated cells, showing it can quantify intravasation rates and test anti-metastatic drugs.

Biofabrication · Jul 7, 2026Peer-reviewedBioengineering

Remodeling of self-assembled microvascular networks under long term flow

Marie A. Floryan, Elena Cambria, Adriana Blazeski, Mark F. Coughlin, Zhengpeng Wan, Giovanni S. Offeddu, Vinayak Vinayak, Aayush Kant, Jordan A. Whisler, Vivek B. Shenoy, Roger Dale Kamm

This study shows that long-term flow can maintain and remodel microvascular networks in a microphysiological system for 51 days, reducing inflammation and enabling vascular remodeling.

npj Biological Physics and Mechanics. · Nov 4, 2025Peer-reviewedBiophysics

Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution Imaging

Monika Dhankhar, Zixian Guo, Aayush Kant, Ramin Basir, Rohit Joshi, Vinayak Vinayak, Su Chin Heo, Robert L. Mauck, Melike Lakadamyali, Vivek B. Shenoy

This study combines theoretical modeling and high-resolution imaging to reveal how chromatin-lamina interactions and environmental cues influence LAD formation and thickness in hMSCs.

Nature Communications · Aug 25, 2025Peer-reviewedBiophysics

Polymer Model Integrates Super-Resolution Imaging and Epigenomic Sequencing to Elucidate the Role of Epigenetic Reactions in Shaping 4D Chromatin Organization

Vinayak Vinayak, Ramin Basir, Rosela Golloshi, Joshua M. Toth, Lucas E. Sant’Anna, Melike Lakadamyali, Rachel Patton McCord, Vivek B. Shenoy

The paper develops a polymer model integrating super-resolution imaging and epigenomic sequencing to show how epigenetic reactions shape 4D chromatin organization and influence gene expression and metastatic potential.

Nature Communications · Apr 23, 2025Peer-reviewedBiophysics