Brice Murciano

The paper shows how multiple RNA binding domains in Unr mediate poly(A) specificity and interact with poly(A) binding protein during translation regulation.

The paper determines the structure of UAF bound to DNA and TBP to reveal how UAF selects RNA Polymerase I for ribosome biogenesis and mediates specific protein-DNA interactions.

The paper reports high-resolution cryo-EM structures of human RNA polymerase I, revealing structural features and disease-related mutations.

The paper characterizes the quaternary hunchback mRNA repression complex formed by Brat, Pum, and Nanos, revealing its flexibility and independent binding of RNA components.