Agata D. Misiaszek

Quantitative comparison of methodologies for translation site imaging in living cells

This study compares translation site imaging methods in living cells, finding that the ALFA-tag minimizes mRNA expression perturbations and enhances fluorescent signal.

Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters

The paper presents cryo-EM structures of the SNAPc-containing Pol III PIC on the U6 snRNA promoter and identifies structural differences in SNAPc engagement between Pol III and Pol II PICs.

Cryo-EM structures of human RNA polymerase I

The paper reports high-resolution cryo-EM structures of human RNA polymerase I, revealing structural features and disease-related mutations.

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states

The paper presents cryo-EM structures of human RNA polymerase III in unbound and transcribing states, revealing structural insights into its function and disease associations.