Maria Fernanda Pessano Fialho

This study identifies synaptic vesicle endocytosis in nociceptors as a driver of chronic pain and shows that targeting it with CRISPR/dCas9-R via lipid nanoparticles provides long-lasting pain relief without affecting acute pain responses.

This study shows that PAR2 endosomal signaling amplifies and sustains histamine-induced pain in IBS by maintaining H1R activity.