Single-cell multi-omic analysis of thymocyte development reveals drivers of CD4/CD8 lineage commitment
Zoë Steier, Dominik A. Aylard, Laura Lynn McIntyre, Isabel Baldwin, Esther Jeong Yoon Kim, Lydia Kay Lutes, Can Ergen, Tse-Shun Huang, Ellen A. Robey, Nir Yosef, Aaron Streets
This study uses CITE-seq to analyze thymocyte development and identifies TCR signaling waves and the TCR/calcineurin/NFAT/GATA3 axis as drivers of CD4/CD8 lineage commitment.
bioRxiv · Jul 12, 2021 · PreprintImmunology