Arthur J. Campbell

Discovery of GluA3 preferring AMPA receptor positive allosteric modulator BRD3290

This study discovers BRD3290, a GluA3-preferring AMPA receptor PAM, but finds it does not improve cognitive function in mice despite target engagement.

Genomics 2 Proteins portal: A resource and discovery tool for linking genetic screening outputs to protein sequences and structures

The paper introduces the Genomics 2 Proteins Portal, which links genetic variants to protein sequences and structures to aid in understanding disease mechanisms and therapeutic design.

Differential Functional Consequences of GRIN2A Mutations Associated with Schizophrenia and Neurodevelopmental Disorders

This study investigates how different GRIN2A mutations linked to schizophrenia, epilepsy, and developmental disorders affect NMDA receptor function, revealing distinct functional consequences.

Structural mapping of GABRB3 variants reveals genotype-phenotype correlation

The paper analyzes GABRB3 variants in a cohort of 71 individuals to identify genotype-phenotype correlations, finding associations between variant locations and specific clinical features.

Predicting Functional Effects of Missense Variants in Voltage-Gated Sodium and Calcium Channels

The paper predicts functional effects of missense variants in voltage-gated sodium and calcium channels using machine learning, achieving high accuracy in distinguishing gain and loss of function variants.

Burden analysis of missense variants in 1,330 disease-associated genes on 3D provides insights into the mutation effects

The paper analyzes missense variants in 1,330 disease genes using 3D protein structures to identify mutational hotspots and their functional impact.