Regulation of airway fumarate by host and pathogen promotes S. aureus pneumonia
Ying-Tsun Chen, Zihua Liu, Dario Fucich, Stefano G. Giulieri, Zhe Liu, Ridhima Wadhwa, Gustavo Rios-Delgado, Henning Henschel, N. Tyagi, Françios A.B. Olivier, Ian R. Monk, Shivang S. Shah, Shwetha Hara Sridhar, Marija Drikic, Colleen M. Bianco, , Tania Wong Fok Lung
This study shows that fumarate, regulated by host and pathogen, limits S. aureus growth by blocking metabolic pathways, while FumC enables adaptation through fumarate degradation and utilization.
Nature Communications · Aug 1, 2025Peer-reviewedMicrobiology