This study identifies two sRNAs in Staphylococcus aureus that regulate zinc homeostasis, showing their role in Zn-sparing responses and adaptation to metal limitation.

Nucleic Acids Research · Sep 7, 2026Peer-reviewedMicrobiology

Regulation of airway fumarate by host and pathogen promotes S. aureus pneumonia

Ying-Tsun Chen, Zihua Liu, Dario Fucich, Stefano G. Giulieri, Zhe Liu, Ridhima Wadhwa, Gustavo Rios-Delgado, Henning Henschel, N. Tyagi, Françios A.B. Olivier, Ian R. Monk, Shivang S. Shah, Shwetha Hara Sridhar, Marija Drikic, Colleen M. Bianco, , Tania Wong Fok Lung

This study shows that fumarate, regulated by host and pathogen, limits S. aureus growth by blocking metabolic pathways, while FumC enables adaptation through fumarate degradation and utilization.

Nature Communications · Aug 1, 2025Peer-reviewedMicrobiology

The Staphylococcus aureus small non-coding RNA IsrR regulates TCA cycle activity and virulence

Gustavo Rios-Delgado, Aubrey K. G. McReynolds, Emma A. Pagella, Javiera Norambuena, Paul Briaud, Vincent Zheng, Matthew J. Munneke, Ji‐Sun Kim, Hugo Racine, Ronan K. Carroll, Ehud Zelzion, Eric Patrick Skaar, Jeffrey L. Bose, Dane Parker, David Lalaouna, Jeffrey M. Boyd

This study shows that the small non-coding RNA IsrR in S. aureus regulates TCA cycle activity and virulence by controlling acnA expression and Fe uptake.

Nucleic Acids Research · Dec 4, 2024Peer-reviewedMicrobiology