Philip M. Hansbro

IL-1β and TNF drive endothelial dysfunction and coagulopathy in acute COVID-19.

This study identifies TNF and IL-1β as key drivers of endothelial dysfunction and coagulopathy in acute SARS-CoV-2 infection using in vitro and in vivo models.

A Single Chimeric Spike Antigen Induces Pan-Sarbecovirus Immunity

This study develops a chimeric spike antigen vaccine (CoVEXS5) that induces broad immunity against multiple SARS-CoV-2 variants and other sarbecoviruses in animal models.

Crucial role for iron metabolism in mediating influenza A virus infection and associated disease

This study shows that iron metabolism influences influenza A virus infection and disease by altering gene expression, increasing viral titer, and worsening inflammation, with TFR1 inhibition offering protection.

A COVID-19 Rapid Antigen Test Employing Upconversion Nanoparticles

This paper develops a rapid antigen test using upconversion nanoparticles for COVID-19, achieving high sensitivity and specificity in clinical trials.

Interaction of osteoprotegerin with fibulin-1 is essential for extracellular matrix deposition in fibrotic lung tissue

This study investigates the interaction between osteoprotegerin and fibulin-1 in lung fibrosis, finding they form a complex with fibulin-1 bridging OPG and LTBP1, influencing extracellular matrix deposition.

SOX9-regulated matrix proteins predict poor outcomes in patients with COVID-19 and pulmonary fibrosis