The functional impact of LGI1 autoantibodies on human CA3 pyramidal neurons
Laura Monni, Hans‐Christian Kornau, Alice Podestà, Rosanna P. Sammons, Andrea Sannio, Alexander Stumpf, Thilo Kalbhenn, Matthias Simon, Thomas Sauvigny, Julia Onken, Harald Prüß, Jörg RP Geiger, Martin Holtkamp, Dietmar Schmitz, Pawel Fidzinski
This study examines the effects of LGI1 autoantibodies on human CA3 neurons using ex vivo slices, revealing increased neuronal activity and distinct mechanisms from potassium channel blockers.
Proceedings of the National Academy of Sciences · May 18, 2026Peer-reviewedNeuroscience