Author

James P. Roy

University of CambridgeORCID 0000-0001-9178-8953Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Bidesh MahataiD· 1 shared Bing Li· 1 shared Christopher J. Ward· 1 shared Daniel F. HeraghtyiD· 1 shared David KlenermaniD· 1 shared Debasis BanikiD· 1 shared Jhuma PramanikiD· 1 shared Michael A. Chapman· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Bidesh MahataORCID

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1 paper

Recent·Most cited

Hyaluronidase unlocks sequestered CEACAM5 and improves CAR T-cell therapy in colorectal cancer

Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel F. Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman

This study shows that hyaluronidase improves CEACAM5 accessibility on colorectal cancer cells, enhancing CAR T-cell therapy effectiveness by reducing glycocalyx thickness and restoring sustained T-cell activation.

Advanced Science · Jan 22, 2026Peer-reviewedImmunology