Tobias Busche

The paper identifies SamI as a cytosolic SPFH protein that couples membrane stress to differentiation in Bacillus subtilis by stabilizing a membrane complex involved in stress signaling and biofilm formation.

This study shows that the YqeK hydrolase regulates Ap4A levels in S. aureus, affecting growth, stress survival, biofilm formation, and virulence.

The paper identifies molecular mechanisms driving chemodiversity in Tanacetum vulgare, proposing a new model where chemodiversity is selected for at the population level rather than being a reservoir for later selection.

This study identifies and characterizes the genetic and regulatory mechanisms of xanthan utilization in Microbacterium xanthanicum UB-LE1, revealing conserved and lineage-specific features of this polysaccharide degradation system.

The paper describes the engineering of Bacillus methanolicus to enhance L-glutamate and GABA production through systems-level analysis and metabolic engineering.

The paper maps sigma54 DNA binding sequences in Pseudomonas putida using a data-driven approach combining DNA libraries, RNA aptamers, and deep sequencing, revealing 64,966 distinct motifs.

This study identifies an unusual glycerol-3-phosphate dehydrogenase in Sulfolobus acidocaldarius involved in glycerol degradation, showing its essential role in growth on glycerol.

The paper shows that adding 5'-UTRs from S. acidocaldarius improves plasmid-based protein production, with the alba 5-UTR increasing yield fourfold.

This study shows HPV+ HNSCC cells lose viability during myocyte-like differentiation in vitro, with upregulated myofibril markers and potential therapeutic implications.

The paper constructs genome-reduced strains of S. lividans to enhance heterologous protein secretion, finding improved secretion levels and altered metabolic and stress responses.

The paper develops a workflow to enrich newly synthesized proteins in microbial communities using BONCAT and click chemistry, demonstrating its application in tracing microbial activity.

This study shows that ASF1 histone binding is essential for fertility in Sordaria macrospora, but not for genome stability, and identifies a chromosomal duplication linked to the mutant phenotype.