An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity
M. Bose, Hans J. Oh, John D. Sears, Chun‐Hsing Chen, Anand G. Vala, Shubin Liu, Kacey Marie Talbot, Mohammad Anwar Hossain, Peter J. Brown, Scott Houliston, Julia Garcia Perez, Fengling Li, Meareg Amare, Peter Halfmann, Jessica Louise Smith, , Timothy Mark Willson
The paper describes the enantioselective resolution of a chemical probe targeting CHIKV nsP2 helicase, showing potent antiviral activity for one enantiomer and low activity for the other.
ACS Infectious Diseases · Jul 18, 2025Peer-reviewedPharmacology & Toxicology