Hans J. Oh

An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

The paper describes the enantioselective resolution of a chemical probe targeting CHIKV nsP2 helicase, showing potent antiviral activity for one enantiomer and low activity for the other.

Identification of Direct-acting nsP2 Helicase Inhibitors with Anti-alphaviral Activity

This paper identifies and optimizes oxaspiropiperidine inhibitors targeting nsP2hel, showing nanomolar antiviral activity against multiple alphaviruses.

Structures of the human transcription factor brachyury offer insights into DNA recognition, and identify small molecule binders for the development of degraders for cancer therapy

This study determines the structure of human brachyury, identifies DNA binding insights and a G177D variant, and discovers small molecule binders for potential cancer therapy.