Author

Anand G. Vala

Piramal (India)ORCID 0000-0002-2186-820XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

John D. SearsiD· 2 shared Mark T. HeiseiD· 2 shared Mohammad Anwar HossainiD· 2 shared Nathaniel J. MoormaniD· 2 shared Peter J. BrowniD· 2 shared Timothy Mark WillsoniD· 2 shared Alec J. HirschiD· 1 shared Anirban GhoshaliD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersPharmacology & Toxicology

John D. SearsORCID

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2 papers

Recent·Most cited

An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

M. Bose, Hans J. Oh, John D. Sears, Chun‐Hsing Chen, Anand G. Vala, Shubin Liu, Kacey Marie Talbot, Mohammad Anwar Hossain, Peter J. Brown, Scott Houliston, Julia Garcia Perez, Fengling Li, Meareg Amare, Peter Halfmann, Jessica Louise Smith, , Timothy Mark Willson

The paper describes the enantioselective resolution of a chemical probe targeting CHIKV nsP2 helicase, showing potent antiviral activity for one enantiomer and low activity for the other.

ACS Infectious Diseases · Jul 18, 2025Peer-reviewedPharmacology & Toxicology

Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Anti-alphavirus Activity

Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Peter J. Brown, Meganathan Nandakumar, Anand G. Vala, Eric M. Merten, John D. Sears, Isabella Law, Jane Burdick, Noah L. Morales, Sumera Perveen, Kenneth H. Pearce, Konstantin Popov, Nathaniel J. Moorman, , Timothy Mark Willson

The paper identifies potent covalent inhibitors of Chikungunya nsP2 protease and establishes structure-activity relationships to guide inhibitor design.

Journal of Medicinal Chemistry · Sep 5, 2024Peer-reviewedCell Biology