Interkingdom glycine conjugates of indole-3-carboxylates are Ah receptor ligands
Ethan W. Morgan, Andrew J. Annalora, Denise M. Coslo, Krishne Gowda, Dhimant H. Desai, Fangcong Dong, Ethan w. Davis, Iain A. Murray, Fuhua Hao, Imhoi Koo, Kristina S. Petersen, Penny M. Kris‐Etherton, Trenton M. Wolfe, Reece Erickson, Seth T. Walk, , Gary H. Perdew
The paper identifies glycine-conjugated indole-3-carboxylates as AHR ligands, showing human-specific activation and microbial/host-mediated metabolism.
bioRxiv · May 14, 2026 · PreprintBiochemistry