Author

Benjamin J. Mortishire-Smith

GlaxoSmithKline (United Kingdom)ORCID 0000-0002-0733-1676Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew J. Powell· 1 shared Aurora Irene IdilliiD· 1 shared Cesira de ChiaraiD· 1 shared David HouseiD· 1 shared Elliot FellowsiD· 1 shared Emma E. CawoodiD· 1 shared Federica RaguseoiD· 1 shared Fernanda Teixeira SubtiliD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Andrew J. Powell

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1 paper

Recent·Most cited

Phenotype-first covalent fragment screening identifies a synthetic lethal TYMS inhibitor in ATRX-deficient cells

Federica Raguseo, Elliot Fellows, Cesira de Chiara, Benjamin J. Mortishire-Smith, Sandra Segura‐Bayona, Emma E. Cawood, Ming Jiang, Fernanda Teixeira Subtil, Aurora Irene Idilli, William J. McCarthy, Michael Howell, Katrin Rittinger, James I. MacRae, Mark J. Skehel, Andrew J. Powell, , Simon J. Boulton

The paper identifies a covalent fragment inhibitor of TYMS that selectively kills ATRX-deficient cells through replication stress.

bioRxiv · Jun 11, 2026 · PreprintCell Biology