Author

Qian Chen

Brown University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Bioengineering· 1 Cell Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Tomozumi ImamichiiD· 2 shared Adam Ruppert· 1 shared Alexander S. BrodskyiD· 1 shared Antony K. CheniD· 1 shared Aryana Famili-YouthiD· 1 shared Ayesha Siddique· 1 shared Bing SheniD· 1 shared Changhui LiiD· 1 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

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2 shared papersImmunology

Tomozumi ImamichiORCID

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

IL-27 Reduces Cell-Surface LDLR in Human Macrophages and Restricts VSV-G-Pseudotyped HIV infection

Qian Chen, Udeshika Kariyawasam, Mayra Marquez, Jordan B. Metz, Jun Yang, Adam Ruppert, Tomozumi Imamichi

This study shows IL-27 reduces cell-surface LDLR in macrophages and limits VSV-G-pseudotyped HIV infection through receptor downregulation and post-entry mechanisms.

bioRxiv · Oct 28, 2026 · PreprintImmunology

PA-SfM: Tracker-free freehand 3D photoacoustic imaging via differentiable acoustic radiation

Shuang Li, Jianqi Gao, Chulhong Kim, Seongwook Choi, Hao Huang, Yibing Wang, Junhui Shi, Qian Chen, Shuang Wu, Yu Zhang, Yi Zhou, Yao Yao, Changhui Li

PA-SfM enables tracker-free freehand 3D photoacoustic imaging with improved spatial coverage and reconstruction quality compared to traditional methods.

bioRxiv · Sep 25, 2026 · PreprintBioengineering

Manganese mediates antiviral effects by driving an ATM -TBK1 phosphorylation signaling pathway

Hongyan Sui, Rosana A. Wiscovitch-Russo, Silvia Cachaco, Jun Yang, Whitney Bruchey, Sylvain Laverdure, Qian Chen, Tomozumi Imamichi

This paper identifies a manganese-induced ATM-TBK1 phosphorylation pathway that enhances antiviral immunity by promoting cytokine production and suppressing HIV replication.

Frontiers in Immunology · Nov 19, 2025Peer-reviewedImmunology

The E3 ligase NEDD4L prevents colorectal cancer liver metastasis via degradation of PRMT5 to inhibit the AKT/mTOR signaling pathway

Zhewen Dong, Xiaofei She, Junxian Ma, Qian Chen, Yaqun Gao, Ruiyan Chen, Huanlong Qin, Bing Shen, Hua Gao

Advanced Science · Apr 25, 2025Peer-reviewedCancer Biology

Aberrant expression of collagen type X in solid tumor stroma is associated with EMT, immunosuppressive and pro-metastatic pathways, bone marrow stromal cell signatures, and poor survival prognosis

Elliot H. H. Youth, Aryana Famili-Youth, Dongfang Yang, Ayesha Siddique, Elizabeth Yiru Wu, Wenguang Liu, Murray B. Resnick, Qian Chen, Alexander S. Brodsky

This study identifies COL10A1-associated gene networks in breast and pancreatic cancer that link to EMT, immunosuppression, metastasis, and poor prognosis.

BMC Cancer · Feb 12, 2025Peer-reviewedCancer Biology

Osterix Facilitates Osteocytic Communication by Targeting Connexin43

Zuping Wu, Qian Chen, Qian Gao, Muchun Liang, Yumeng Zhou, Li Zhu, Jiahe Wang, Yang Shen, Junjun Jing, Jing Xie, Xiaoheng Liu, Shujuan Zou, Demao Zhang, Chenchen Zhou

This study shows Osterix maintains osteocytic dendrites and intercellular communication by regulating Connexin43, impacting bone homeostasis and disease.

bioRxiv · Sep 9, 2024 · PreprintCell Biology

Effects of Sanhuang plaster on expression of MyD88, TRAF6, MIP-1β and IL-23 in rats infected by MRSA

Haibang Pan, Qian Chen, Qi Fu, Tianming Wang, Xiaoli Li, Richeng Li, Mei Liu, Tiankang Guo

This study evaluates Sanhuang plaster's effect on reducing inflammation markers in MRSA-infected rats by measuring gene and protein expression levels.

bioRxiv · Mar 2, 2022 · PreprintMolecular Biology

Effect of high proportion concentrate dietary on Yak jejunal structure, physiological function and protein composition during cold season

Jianlei Jia, Chunnian Liang, Xiaoyun Wu, Lin Xiong, Pengjia Bao, Qian Chen, Ping Yan

This study examines how high concentrate diets affect Yak jejunal structure, function, and protein composition during cold seasons, finding differences in enzyme activity, morphology, and protein expression between grazing and intensive feeding.

Scientific Reports · Mar 9, 2021Peer-reviewedGenetics

MyoD is a structure organizer of 3D genome architecture in muscle cells

Qian Chen, Fengling Chen, Ruiting Wang, Minglei Shi, Antony K. Chen, Zhao Ma, Guohong Li, Min Wang, Hu Li, Xu Zhang, Jinbiao Ma, Jiayun Zhong, Meihong Chen, Michael Q. Zhang, Yong Zhang, , Dahai Zhu

The paper shows MyoD organizes 3D genome architecture in muscle cells and demonstrates H3K27ac is insufficient for MyoD-induced chromatin loops.

bioRxiv · Aug 29, 2020 · PreprintGenomics