M. Camila Melo-Narváez

Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis

This study shows that loss of TFAM in alveolar type 2 cells leads to mitochondrial dysfunction and fibrosis by promoting senescence and a profibrotic secretory program.

Local IFNγ signaling contributes to the regenerative decline of aged alveolar progenitor cells

This study shows that local IFNγ signaling in aged lungs impairs alveolar progenitor cell regeneration, and reducing IFNγ levels restores regenerative capacity.

Single cell decomposition of multicellular aging programs associated with impaired lung regeneration

The paper uses single-cell RNA-seq to analyze aging effects on lung regeneration, identifying immune cell states linked to impaired progenitor function in aged mice.

SenSet, a novel human lung senescence cell gene signature, identifies cell-specific senescence mechanisms

The paper develops SenSet, a gene signature for human lung senescence, validated in 3D culture models and identifies cell-type specific senescence mechanisms in aging and disease.