Author

Delphine Beaulieu

University of PittsburghORCID 0000-0002-0258-747XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

John SembratiD· 2 shared M. Camila Melo-NarváeziD· 2 shared Mareike LehmanniD· 2 shared Mélanie KönigshoffiD· 2 shared Nayra CárdenesiD· 2 shared Oliver EickelbergiD· 2 shared Qianjiang HuiD· 2 shared Aditi U. GurkariD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPathology

John SembratORCID

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2 papers

Recent·Most cited

Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis

Qianjiang Hu, Ugochi Onwuka, Nayra Cárdenes, M Packwood, E L Huang, Jian Shi, M. Camila Melo-Narváez, Puja Dutta, Zihe Zhou, Delphine Beaulieu, Byron W. Chuan, Pavan Suresh, Kevin Redding, Laura-Marie Twardowski, Scarlett Varley, , Mélanie Königshoff

This study shows that loss of TFAM in alveolar type 2 cells leads to mitochondrial dysfunction and fibrosis by promoting senescence and a profibrotic secretory program.

bioRxiv · Jul 18, 2026 · PreprintPathology

SenSet, a novel human lung senescence cell gene signature, identifies cell-specific senescence mechanisms

Euxhen Hasanaj, Delphine Beaulieu, Cankun Wang, Qianjiang Hu, Marta Bueno, John Sembrat, Ricardo Pineda, M. Camila Melo-Narváez, Nayra Cárdenes, Zhao Yanwu, Zhang Yingze, Robert Lafyatis, Alison Morris, Ana Lucia Mora, Mauricio Rojas, , Mélanie Königshoff

The paper develops SenSet, a gene signature for human lung senescence, validated in 3D culture models and identifies cell-type specific senescence mechanisms in aging and disease.

bioRxiv · Dec 21, 2024 · PreprintGenomics