Simon L. Bullock

This study shows that FXR proteins and BICD2 work together to activate dynein for RNP transport and stress granule formation, revealing separable steps in dynein-mediated transport.

The paper shows that dynein-dependent organelle clustering during oxidative stress enhances gene expression by coordinating organelle positioning.

This study identifies Imp as a regulator of transposable elements and developmental genes, showing its role in suppressing TEs and maintaining genome stability during embryogenesis.

The paper presents cryo-EM structures of Egl-BicD-RNA complexes to show how diverse mRNAs are selected for subcellular localization through shape, sequence, and structured RNA elements.

This study identifies a mechanism by which Centrocortin mRNA is co-translationally localized to centrosomes via dynein, microtubules, and a conserved dynein-binding motif.

This study shows that C9orf72 repeat expansions produce toxic arginine-rich DPRs that disrupt axonal transport by interacting with microtubules and motor proteins, contributing to ALS/FTD.