Author

Florence L. Young

MRC Laboratory of Molecular BiologyORCID 0000-0002-5475-9835Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Aaron D. GitleriD· 1 shared Alexander McCampbelliD· 1 shared Ann Swijsen· 1 shared Arpan R. MehtaiD· 1 shared Bhuvaneish Thangaraj SelvarajiD· 1 shared Carlas SmithiD· 1 shared Catherine M. VerfaillieiD· 1 shared Darragh EnnisiD· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Aaron D. GitlerORCID

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2 papers

Recent·Most cited

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

Laura Fumagalli, Florence L. Young, Steven Boeynaems, Mathias De Decker, Arpan R. Mehta, Ann Swijsen, Raheem Fazal, Wenting Guo, Matthieu Moisse, Jimmy Beckers, Lieselot Dedeene, Bhuvaneish Thangaraj Selvaraj, Tijs Vandoorne, Vanesa Madan, Marka van Blitterswijk, , Philip Van Damme

This study shows that C9orf72 repeat expansions produce toxic arginine-rich DPRs that disrupt axonal transport by interacting with microtubules and motor proteins, contributing to ALS/FTD.

Science Advances · Apr 9, 2021Peer-reviewedNeuroscience

Single Molecule Fluorescence In Situ Hybridisation For Quantitating Post-Transcriptional Regulation In Drosophila Brains

Lu Yang, Josh Titlow, Darragh Ennis, Carlas Smith, Jessica H. Mitchell, Florence L. Young, Scott Waddell, David Ish‐Horowicz, Ilan Davis

This paper applies single-molecule FISH to study post-transcriptional regulation in Drosophila brains by analyzing mRNA distributions and co-visualizing transcripts and proteins.

Methods · Jun 24, 2017Peer-reviewedNeuroscience