Kiara Freitag

SALL1 and neural microenvironmental contextspecify identity of stem cell derived humanmicroglia-like cells

This study identifies how SALL1 and neural microenvironmental context shape the identity of stem cell-derived human microglia-like cells in 2D and 3D cultures.

Synovium-Restricted Armored PD-1-Targeted CAR-T Cells Reprogram Immunity and Resolve Experimental Arthritis

This study develops PD-1-targeted CAR-T cells that specifically eliminate synovium-associated T cells and reduce arthritis in experimental models.

RNA promotes synapsin phase separation providing a platform for local translation

The paper shows RNA promotes synapsin phase separation, forming condensates that organize synaptic vesicles and enhance local translation.

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model

This study shows that spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model by targeting microglia and reducing inflammatory pathways.

Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and aging

The paper compares ESC-derived, neonatal, and adult astrocytes to identify functional and transcriptomic differences across age and culture conditions.

The autophagy activator Spermidine ameliorates Alzheimer's disease pathology and neuroinflammation in mice

This study shows that Spermidine, an autophagy activator, reduces neuroinflammation and Aβ levels in AD-like mice by enhancing autophagy in microglia and astrocytes.