Sean T. Prigge

This study shows that Acyl Carrier Protein (ACP) is essential for apicoplast biogenesis in blood-stage P. falciparum malaria parasites, independent of its role in fatty acid synthesis.

This study identifies essential enzymes in the pyrimidine biosynthesis pathway of Plasmodium falciparum and demonstrates their critical roles in parasite survival.

The paper investigates whether reduced PfPSS expression affects resistance of PfATP4 mutant parasites to antimalarials, finding no significant change in drug efficacy.

This paper identifies PfAnchor as an essential protein for apicoplast fission and inheritance in Plasmodium falciparum, showing its interaction with PfDyn2 and its role in parasite survival.

The paper identifies multiple redundant carboxylic acid transporters in Plasmodium falciparum that support mitochondrial metabolism, revealing metabolic flexibility in the parasite.

This paper identifies and characterizes TilS in the apicoplast of Plasmodium falciparum, showing its essential role in tRNA lysidinylation and parasite survival.

This study challenges the apicoplast-minus concept in Plasmodium falciparum by showing that apicoplast-derived vesicles are inherited and retain four-membrane structures, suggesting a genome-less apicoplast derivative called apicosomes.

This study identifies MnmE and MnmG as essential enzymes for xm5s2U modification in Plasmodium falciparum apicoplast tRNAs, revealing a minimal biosynthetic pathway critical for apicoplast maintenance.

The paper redesigns a TetR-aptamer system to improve stability and efficiency in controlling gene expression in Plasmodium falciparum.