Hannah Dickmänken

Tissue-wide metabolic buffering confers resilience to mitochondrial dysfunction

The paper shows that tissue-wide metabolic buffering allows neural stem cells to maintain proliferation despite mitochondrial dysfunction, highlighting the role of tissue heterogeneity in resilience.

HyDrop v2: Scalable atlas construction for training sequence-to-function models

The paper introduces HyDrop v2, a microfluidic system for generating large scATAC-seq atlases, and shows its data is comparable to commercial platforms for training sequence-to-function models.

Cell type directed design of synthetic enhancers

This study uses deep learning to design synthetic enhancers that target specific cell types in fruit flies and humans, revealing the enhancer code as optimal TF activator motifs and absence of repressor motifs.