Tissue-wide metabolic buffering confers resilience to mitochondrial dysfunction
Stavroula Petridi, Abhilesh S Dhawanjewar, Dnyanesh Dubal, Rajini Chandrasegaram, Hannah Dickmänken, Navaroshini Bala-Muraly, Bryce A. Wilson, Thomas Eve, Bryan P. Marzullo, Antony M. Hynes-Allen, Scott A. Jones, Martin S. King, Richard Butler, Marco Sciacovelli, Edmund R.S. Kunji, , Jelle van den Ameele
The paper shows that tissue-wide metabolic buffering allows neural stem cells to maintain proliferation despite mitochondrial dysfunction, highlighting the role of tissue heterogeneity in resilience.
bioRxiv · Sep 15, 2026 · PreprintDevelopmental Biology