James R. Sellers

This paper develops a FRET-based tension sensor (mDia1TS) to measure mechanical tension in formin-elongated actin filaments in live cells and quantifies changes in tension under different conditions.

The paper presents the cryo-EM structure of human NM2B in the autoinhibited 10S conformation, revealing structural mechanisms of autoinhibition and implications for disease.

The paper shows myosin forces alter F-actin structure, creating a landscape that -catenin recognizes, revealing a mechanism for mechanosensitive signaling.

This study investigates how specific MYH9 mutations affect NM2-A aggregation and intracellular dynamics, revealing differences in their molecular impact on cellular function and disease severity.

The paper identifies a protective pathway where LLO-induced Src activation phosphorylates NMHC2A, enabling cytoskeletal reorganization and PM damage response, conserved in C. elegans.

This study shows that actin network contractile steady states can be sustained by filament transport rather than assembly/disassembly in an in vitro system.

This paper develops a selective non-muscle myosin II inhibitor, MT-228, with high brain penetration and efficacy in preclinical models, offering therapeutic potential for diseases like stimulant use disorder.