Reda Chalhoub

This study uses a non-linear clustering approach in rats to identify distinct behavioral and neuronal profiles associated with heroin vulnerability and resiliency, reflecting human opioid use disorder heterogeneity.

The paper shows that cocaine-trained mice have stable D1-MSNs in the NAcore that predict cue-induced cocaine seeking, unlike sucrose.

This study identifies D2-MSN hyperactivity as a driver of antipsychotic-induced behavioral supersensitivity and its associated symptoms.