The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation
Feng Li, Tsz Y. Lo, Leann Miles, Qin Wang, Harun Najib Noristani, Dan Li, Jingwen Niu, Shannon Trombley, Jessica I. Goldshteyn, Chuxi Wang, Shuchao Wang, Jingyun Qiu, Katarzyna Pogoda, Kalpana Mandal, Megan Brewster, , Yuanquan Song
This study identifies the Piezo-Atr-Chek1-Cdc25 pathway as an inhibitory mechanism for axon regeneration, showing that disrupting it enhances regeneration in Drosophila and mammals.
Nature Communications · Jun 22, 2021Peer-reviewedNeuroscience