Attilio Iemolo

Functional specialization of the hippocampus along its dorso-ventral axis: from span to supraspan in working memory capacity

This study establishes a rodent model of supraspan memory and shows that dorsal hippocampus supports high-load memory while ventral hippocampus supports egocentric strategies.

Single-nucleus transcriptomics reveals convergent effects of THC exposure and Reelin signaling on nucleus accumbens maturation in adolescence

This study uses single-nucleus RNA sequencing to show that adolescent THC exposure and reduced Reelin signaling both affect nucleus accumbens maturation through shared gene networks linked to substance use and psychiatric disorders.

Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions

This study examines sex-biased gene expression changes in mouse brain regions after adolescent THC exposure, identifying common regulatory mechanisms linked to cannabis use disorder vulnerability.

Reelin deficiency exacerbates cocaine-induced hyperlocomotion by enhancing neuronal activity in the dorsomedial striatum.

This study shows that Reelin deficiency increases cocaine-induced hyperlocomotion in mice by enhancing neuronal activity in the dorsomedial striatum, without affecting cocaine reward.

Reelin deficiency contributes to long-term behavioral abnormalities induced by chronic adolescent exposure to Δ9-tetrahydrocannabinol in mice

This study shows that Reelin deficiency exacerbates long-term behavioral issues in mice exposed to THC during adolescence, including impaired social behavior and increased novelty seeking.