Laura K. Hilton

Developmental origins of thymic B-cell lymphomas

This study identifies a thymus-specific B-cell differentiation program linked to thymic B-cell lymphomagenesis through single-cell multiomics and spatial profiling.

A patient derived xenograft repository capturing clinical and molecular heterogeneity of large B-cell lymphoma

The paper establishes a PDX repository of large B-cell lymphoma models capturing clinical and molecular diversity, including post-CART19 progression cases.

LCR-modules: a collection of workflows for cancer genome analysis

LCR-modules provides a flexible, automated suite of workflows for cancer genome analysis, supporting diverse sequencing types and enabling reproducible, scalable analysis of over 10,800 samples.

Multidimensional characterization of cellular ecosystems in Hodgkin lymphoma

This study identifies four molecular subtypes of Hodgkin lymphoma using multimodal data, revealing distinct clinical features and immune ecosystem dynamics.

Robust gene expression-based classification of cancers without normalization

This paper introduces a self-training method for gene expression-based cancer classification that works across different data types and normalization methods.

Genome-wide discovery of somatic coding and regulatory variants in Diffuse Large B-cell Lymphoma

This study identifies somatic coding and regulatory variants in DLBCL, revealing novel mechanisms of oncogene deregulation and potential therapeutic targets.