Yue Liu

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.

This study conducts a genome-wide association analysis of the Big Five personality traits, identifying novel genetic loci and associations with psychiatric traits.

Large-Scale Deep Multi-Layer Analysis of Alzheimer's Disease Brain Reveals Strong Proteomic Disease-Related Changes Not Observed at the RNA Level

The paper analyzes proteomic data from Alzheimer's disease brains, revealing disease-related changes not seen at the RNA level and identifying potential therapeutic targets.

Multi-Tissue Neocortical Transcriptome-Wide Associations Study Implicates 8 Genes Across 6 Genomic Loci in Alzheimer's Disease

This paper identifies 8 genes across 6 genomic loci associated with Alzheimer's disease risk using transcriptome-wide association study and validates them with summary Mendelian randomization.

Genetic control of the human brain proteome

The paper identifies pQTLs for brain proteins and finds they differ from eQTLs, suggesting distinct genetic control of mRNA and protein abundance.

Cerebral atherosclerosis contributes to Alzheimer’s dementia independently of its hallmark amyloid and tau pathologies

This study identifies 114 proteins and 5 modules linked to cerebral atherosclerosis in the brain, with 23 proteins and 2 modules also associated with Alzheimer’s dementia, highlighting shared mechanisms involving synaptic signaling and myelination.