Michael N. Economo

BiXformer disentangles bidirectional neural communication by modeling causal and acausal streams, revealing temporally structured components in neural dynamics.

The paper investigates how excitation and inhibition shape theta-gamma coupling in the medial entorhinal cortex using experimental and computational methods, revealing distinct cell-type contributions to oscillatory activity.

The paper shows that motor cortical involvement in movement changes rapidly and depends on task structure and sensorimotor uncertainty.

The paper investigates how neural subspaces are mapped in the mouse motor system, finding that specific cell types do not exclusively encode movement-potent dynamics.

The paper introduces an all-optical method to map synaptic connectivity with cell-type specificity using spatial transcriptomics and optical measurements.

This paper demonstrates how to separate cognitive and motor processes in mice using a novel behavioral task and subspace decomposition, revealing distinct neural dynamics for each.

The paper develops a model to predict false discovery rate (FDR) in spike sorting using ISI violations and validates it with simulations and public datasets.

This paper introduces a microscope combining targeted illumination and confocal gating to improve voltage imaging in dense tissues, enhancing signal-to-noise ratio and reducing crosstalk.

The paper identifies a mutation that enhances the sensitivity of a fluorescent voltage indicator, improving its ability to detect both spiking and subthreshold voltage signals in multiple organisms.

The paper uses two-photon calcium imaging and surface electrophysiology to show that only a small fraction of layer 2 neurons follow surface MUA, suggesting MUA may primarily reflect axonal inputs.

The paper develops a high-speed, multi-Z confocal microscope to improve voltage imaging in densely labeled neuronal populations by increasing contrast and speed.

The paper develops a workflow to accurately localize electrodes in Neuropixels probes across multiple brains using imaging and electrophysiological data.

The paper shows that attractor dynamics in the frontal cortex gate sensory information flow during decision-making, making choices more robust to distractors over time.

The paper reconstructs 1,000 projection neurons in the mouse brain, revealing new cell types and organizational principles of long-range connectivity.

The paper identifies two types of motor cortex neurons with distinct roles in movement preparation and execution using single-cell profiling and axonal reconstructions.

The paper identifies shared and distinct transcriptomic cell types in two mouse neocortical regions using scRNA-seq, showing most excitatory types are region-specific while inhibitory types are shared.

The paper investigates how inhalation frequency affects odor representations in mitral/tufted cells of the olfactory bulb, finding frequency-dependent changes in neural activity patterns.