Jayaram V. Chandrashekar

3D-MAESTRO automates processing of large-scale volumetric brain microscopy data, enabling scalable and reproducible analysis of mouse brain structures.

The paper identifies topographic organization in locus coeruleus norepinephrine neurons, linking their morphology, gene expression, and activity to specific brain regions and learning-related behaviors.

The paper introduces ExA-SPIM, a microscope that enables high-resolution imaging of large tissue samples without sectioning, demonstrating its use on mouse brains and human white matter.

HortaCloud provides a cloud-based platform for collaborative whole-brain neuronal reconstruction from light microscopy data, enabling efficient analysis of large datasets without local hardware.

The paper introduces morphoFISH, a method combining imaging and spatial transcriptomics to identify new neuronal cell types in the mouse brain.

The paper visualizes dense distributions of immunolabeled proteins in adult macaque visual cortex using expansion microscopy and light sheet imaging, enabling multimodal atlas creation.

The paper reconstructs 1,000 projection neurons in the mouse brain, revealing new cell types and organizational principles of long-range connectivity.

The paper identifies two types of motor cortex neurons with distinct roles in movement preparation and execution using single-cell profiling and axonal reconstructions.

This study compares somatotopic precision in corticostriatal projections from two cortical cell types, finding IT-type neurons show higher stereotypy than PT-type neurons.

The paper identifies homeobox transcription factors as key drivers of neuronal diversity through improved expression metrics and links long genes to regulatory elements and mobile elements.