Author

Siri Tähtinen

GenentechORCID 0000-0003-1237-0730Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alan Gutierrez· 2 shared Anthony C. AntonelliiD· 2 shared Camille-Charlotte BalançaiD· 2 shared Emily C. FreundiD· 2 shared Ira MellmaniD· 2 shared Jill M. Schartner· 2 shared Lélia DelamarreiD· 2 shared Milena Hornburg· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Alan Gutierrez

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3 papers

Recent·Most cited

Cross-competition shapes CD8+ T cell hierarchies and differentiation after RNA vaccination

Mark J. McCarron, Milena Hornburg, Thomas D. Wu, Ann-Jay Tong, Siri Tähtinen, Martine Darwish, Emily C. Freund, Ying Feng, David Eisel, Camille-Charlotte Balança, Itai Doron, Huan Lan, Sophie M. Lehar, Tamaki Nozawa, Yoko A. Oei, , Lélia Delamarre

The paper investigates how immunodominance affects CD8+ T cell differentiation and hierarchy after RNA vaccination, finding that dominant responses influence subdominant ones through cross-competition.

bioRxiv · Oct 26, 2025 · PreprintImmunology

Predictive in vitro profiling of LNP-induced innate immune response using an iPSC-derived monocyte model

Baixue Xiao, Soojin Kim, Benjamin I Laufer, Anthony Antonelli, Milena Hornburg, Divya Murali, Yimin Gu, Pierce Jessen, Diamanda Rigas, Rebecca Leylek, Keiko Hokeness, Emily Freund, Eric Torres, Gaia Ruggeri, Siri Tahtinen, , Maheswara Reddy Emani

This study develops an iPSC-derived monocyte model to predict LNP-induced innate immune responses, showing improved reproducibility and correlation with in vivo cytokine responses.

bioRxiv · Sep 26, 2025 · PreprintBioengineering

A single MHCII neoepitope mRNA vaccine elicits CD4 T- and B- cell responses promoting endogenous CD8 anti-tumor immunity

Aude-Hélène Capietto, Camille-Charlotte Balança, Romain Bouziat, Thomas D. Wu, Joshua G. Gober, Catherine B. Carbone, Ariane Nissenbaum, Reyhane Hoshyar, Marshleen Yadav, Alan Gutierrez, Yajun Chestnut, Vincent Javinal, Hari Menon, Spyros Darmanis, Marco Claudio De Simone, , Jonathan L. Linehan

bioRxiv · Jun 9, 2025 · PreprintImmunology