This study identifies multicellular spatial molecular programs in meningiomas using multi-omic data and develops a model to infer these programs from histopathology.

bioRxiv · Jun 17, 2026 · PreprintCancer Biology

A mitochondrial program encodes brain vascular reserve

Ivan Fan Xia, Di Zhang, A. Gulhan Ercan‐Sencicek, Tanyeri Barak, Anupama Hemalatha, David G. Gonzalez, Jared Hintzen, Paola Carneiro, Gabriel Baldissera, Marina Carlson, Siyuan Cheng, Fei Han, Xinzhuang Yang, Lu Feng, Nicole J. Lake, , Stefania Nicoli

The paper shows mitochondrial state in zebrafish tip cells encodes brain collateral network topology, with microRNA-125a regulating mitochondrial function to influence vascular resilience.

bioRxiv · Mar 26, 2026 · PreprintDevelopmental Biology

Non-invasive approach for endoluminal biopsy coupled with single-cell proteomics allows for immune characterization of intracranial aneurysms

Joseph Paul Antonios, Batur Gültekin, Brianna Carusillo Theriault, Kanat Yalcin, Danielle F. Miyagishima, Nana Adenu‐Mensah, Nanthiya Sujijantarat, Andrew B. Koo, Joseph O Haynes, Paul Anthony Cedeño, Michele H. Johnson, Ryan Matthew Hebert, Charles Christian Matouk, Tanyeri Barak, Murat Günel

This study uses endoluminal biopsy and single-cell proteomics to analyze immune profiles in intracranial aneurysms, identifying immune signatures linked to aneurysm stability and rupture.

bioRxiv · Feb 17, 2025 · PreprintPhysiology

Genetic dysregulation of an endothelial Ras signaling network in vein of Galen malformations

Shujuan Zhao, Kedous Y. Mekbib, Martijn A. van der Ent, Garrett Allington, Andrew E. Prendergast, Jocelyn E. Chau, Hannah Louise Smith, John P. Shohfi, Jack Ocken, Daniel Durán, Charuta Gavankar Furey, Hao Thi Le, Phan Q. Duy, Benjamin C. Reeves, Junhui Zhang, , Kristopher Thomas Kahle

The paper identifies genetic variants in RASA1 and EPHB4 associated with vein of Galen malformations through exome analysis and single-cell transcriptomics.

bioRxiv · Mar 18, 2023 · PreprintGenomics

spARC Recovers Human Glioma Spatial SignalingNetworks with Graph Filtering

Manik Razdan Kuchroo, Danielle F. Miyagishima, Holly R. Steach, Abhinav Godavarthi, Yutaka Takeo, Phan Q. Duy, Tanyeri Barak, Zeynep Erson-Omay, Scott E. Youlten, Ketu Mishra-Gorur, Jennifer A. Moliterno, Declan McGuone, Murat Günel, Smita Krishnaswamy

The paper introduces spARC, a method to recover spatial signaling networks in gliomas, revealing an Osteopontin-CD44 interaction enriched in grade IV astrocytomas.

bioRxiv · Aug 24, 2022 · PreprintBioinformatics