Author

Scott W. MacDonald

Ragon Institute of MGH, MIT and HarvardORCID 0000-0002-0110-4026Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alejandro Benjamin BalazsiD· 2 shared Adam D. NitidoiD· 1 shared Allen Z. LiniD· 1 shared Amarendra PeguiD· 1 shared Benjamin MooniD· 1 shared Cailin E. Deal· 1 shared Callaghan R. GarlandiD· 1 shared Christine L. BoutrosiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Alejandro Benjamin BalazsORCID

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2 papers

Recent·Most cited

Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice

Matthew D. Slein, Lesle M Jimenez, Iara M. Backes, Evelyn M. Turnbaugh, Callaghan R. Garland, Scott W. MacDonald, Alejandro Benjamin Balazs, David A. Leib, Margaret E. Ackerman

This study shows that gB-targeting antibodies protect neonatal mice from HSV infection, requiring both neutralization and Fc effector functions, with transgenerational protection achievable via AAV-mediated delivery.

Journal of Virology · Mar 9, 2026Peer-reviewedImmunology

HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV vectored immunotherapy in humanized mice

Nicolás M. S. Gálvez, Adam D. Nitido, Seo Bin Yoo, Yi Cao, Cailin E. Deal, Christine L. Boutros, Scott W. MacDonald, Yentli E. Soto Albrecht, Evan Christopher Lam, Maegan L. Sheehan, Dylan Parsons, Allen Z. Lin, Martin J. Deymier, Jacqueline M. Brady, Benjamin Moon, , Alejandro Benjamin Balazs

This paper uses humanized mice to study how HIV resistance to broadly neutralizing antibodies (bNAbs) affects the efficacy of AAV-delivered immunotherapy, finding that escape mutation fitness costs and resistance benefits determine therapeutic success.

Immunity · Feb 25, 2026Peer-reviewedMicrobiology