Hilde Herrema

Diversity-generating retroelements enable phages to expand their host range in the human gut.

The paper tracks phage-host interactions in the human gut and finds that DGR-encoding phages interact with multiple bacterial species and show increased nucleotide diversity in their receptor-binding proteins.

Ethnic differences in gut microbiota composition and functional capacity persist over six years in the HELIUS multi-ethnic longitudinal cohort

The paper tracks ethnic differences in gut microbiota composition and function over six years in a multi-ethnic cohort, finding persistent disparities despite shared environment.

Sex-stratified adipose-liver circuits in human MASLD

This study identifies sex-specific transcriptional differences in liver and visceral adipose tissue in MASLD and shows coordinated cross-tissue states.

CLR-Seq: a pipeline to identify bacterial microbiota species with immune-relevant glycan moieties through human C-type lectin receptor interaction

CLR-seq identifies bacterial species with immune-relevant glycans by using C-type lectin receptors and 16S rRNA sequencing in human microbiota samples.

Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction

This study shows that gut-derived bacterial flagellin contributes to beta-cell inflammation and dysfunction in type 2 diabetes.

Systems analysis of metabolic responses to a mixed meal test in an obese cohort reveals links between tissue metabolism and the gut microbiota

The paper analyzes metabolic responses to a mixed meal test in an obese cohort, linking tissue metabolism with gut microbiota changes and identifying potential biomarkers for T2DM.