Max Nieuwdorp

The paper tracks phage-host interactions in the human gut and finds that DGR-encoding phages interact with multiple bacterial species and show increased nucleotide diversity in their receptor-binding proteins.

scOmnom provides a scalable, semi-automated workflow for single-cell RNA-seq analysis, enabling auditable clustering-resolution selection and annotation refinement across large datasets.

The paper tracks ethnic differences in gut microbiota composition and function over six years in a multi-ethnic cohort, finding persistent disparities despite shared environment.

This study identifies sex-specific transcriptional differences in liver and visceral adipose tissue in MASLD and shows coordinated cross-tissue states.

This paper develops and validates a GC-QQQ method for measuring unlabeled and 13C6-fructose in human plasma, showing improved sensitivity and lower LLOQs compared to SIM.

This study investigates the role of adipose tissue in dyslipidemia through multi-omics analysis of patients with obesity, identifying inflammation, oxidative stress, and altered adipogenesis as key drivers.

This study shows that gut microbial metabolite imidazole propionate impairs endothelial function and promotes atherosclerosis in both human and animal models.

This study shows that gut-derived bacterial flagellin contributes to beta-cell inflammation and dysfunction in type 2 diabetes.

The paper analyzes metabolic responses to a mixed meal test in an obese cohort, linking tissue metabolism with gut microbiota changes and identifying potential biomarkers for T2DM.